|
KMID : 0613820040140030445
|
|
Journal of Life Science
2004 Volume.14 No. 3 p.445 ~ p.452
|
|
|
Regulation of Bcl-2 Family and Cyclooxygenases by Furanoterpenoids Isolated from a Marine Sponge Sarcotragus sp. in Human Lung Cancer A549 Cells
|
|
Choi Hye-Joung
Kim Nam-Deuk
Jung Jee-Hyung
Choi Yung-Hyun
|
|
|
Abstract
|
|
|
|
We investigated the cytotoxic effects of seven furanoterpenoids [sarcotin A, epi-sarcotin A, ircinin-1, epi-sarcotrine B, sarcotin I, (8E,13Z,20Z)-strobilinin/(7E,13Z, 20Z)-felixinin and (7E,12E,18R,20Z)-variabilin] isolated from the sponge Sarcotragus sp. ( the order Dictyoceratida) on the growth of A549 human lung carcinoma cells. MTT data revealed that sarcotin A and (7E,12E,18R,20Z)-variabilin exhibited higher potencies on the anti-proliferative activities than the other compounds in A549 cells. The growth inhibition by treatment with compounds (especially epi-sarcotin A, ircinin-1 and epi-sarcotrine B) were associated with the induction of apoptotic cell death through the concentration-dependent increase of Bax/Bcl-2 ratio in a p53-dependent or independent pathway. Additionally, epi-sarcotin A and ircinin-1 strongly inhibited the levels of cyclooxygenase (COX)-2 expression without alteration of COX-1. Taken together, the results suggest that the furanoterpenoids from the marine sponge have strong potentials as candidates for anti-cancer drugs.
|
|
|
KEYWORD
|
|
|
furanoterpenoid, sponge, apoptosis, Bcl-2, cyclooxygenase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|